Association of vitamin D receptor gene polymorphisms and serum 25‐hydroxyvitamin D levels with Crohn's disease in Chinese patients
Background and Aim: The vitamin D receptor (VDR) regulates immune responses and inflammation through binding with 1,25-dihydroxyvitamin D, the active form of vitamin D. The serum 25-hydroxyvitamin D (25(OH)D) level clinically reflects vitamin D status in the human body. We investigated the association of VDR polymorphisms and 25(OH)D levels in Chinese patients with Crohn's disease (CD). Methods: Vitamin D receptor polymorphisms ( Fok I, Bsm I, Apa I, and Taq I) were genotyped by SNaPshot . Serum 25(OH)D levels were measured by electro-chemiluminescence immunoassay. Results: A total of 297 patients with CD and 446 controls were recruited. Compared with controls, mutant alleles and genotypes of Bsm I and Taq I were less prevalent in patients with CD (all P Conclusions: Vitamin D receptor ( Bsm I, Apa I, and Taq I) mutations and lower 25(OH)D levels are associated with CD in Chinese patients. Moreover, VDR ( Fok I, Apa I, and Taq I) mutations and vitamin D deficiency may have a combined impact on CD.