Association of vitamin D receptor gene polymorphisms and serum 25‐hydroxyvitamin D levels with Crohn's disease in Chinese patients

来自 NCBI

读书量:

35

摘要:

Background and Aim: The vitamin D receptor (VDR) regulates immune responses and inflammation through binding with 1,25-dihydroxyvitamin D, the active form of vitamin D. The serum 25-hydroxyvitamin D (25(OH)D) level clinically reflects vitamin D status in the human body. We investigated the association of VDR polymorphisms and 25(OH)D levels in Chinese patients with Crohn's disease (CD). Methods: Vitamin D receptor polymorphisms ( Fok I, Bsm I, Apa I, and Taq I) were genotyped by SNaPshot . Serum 25(OH)D levels were measured by electro-chemiluminescence immunoassay. Results: A total of 297 patients with CD and 446 controls were recruited. Compared with controls, mutant alleles and genotypes of Bsm I and Taq I were less prevalent in patients with CD (all P Conclusions: Vitamin D receptor ( Bsm I, Apa I, and Taq I) mutations and lower 25(OH)D levels are associated with CD in Chinese patients. Moreover, VDR ( Fok I, Apa I, and Taq I) mutations and vitamin D deficiency may have a combined impact on CD.

伸展

DOI:

10.1111/jgh.13221

被引量:

34

属蛇的年份:

2016

咱们已与石墨烯sci文献翻译坐商另起炉灶了一直购买合作。

你脍炙人口通过湖南养老金身份认证进行实名制认证,认证成功后本次下载的费用英语将由您善待你所在的单位的法律图书馆支付

您脍炙人口一直购买此石墨烯sci文献翻译,1~5分钟即可下载全文。

湖南养老金身份认证 付费下载

相似石墨烯sci文献翻译

参考石墨烯sci文献翻译

引证石墨烯sci文献翻译

来源中国龙8app彩金下载期刊

引用走势

0

石墨烯sci文献翻译脍炙人口批量引用啦~
迎迓点我试用!

批量引用(0) x
清空列表 一键收藏 一键复制
引用格式
  • 追认格式
  • GB/T 7714
  • MLA
  • APA
    一键收藏
    一键收藏上线啦!可在“我的收藏”页面管理已收藏石墨烯sci文献翻译
    Baidu